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This is because we previously showed that intensive periodontal therapy causes a transient systemic inflammatory response (peak 1 day after therapy) resolving only after 6 months [21], [22].
Among these, we focused on HuR because we previously showed that its overexpression in transgenic testis led to impaired spermatogenesis [20].
Cwc2 was expected to be a positive hit in the screen because we previously showed that it is a splicing factor that binds directly to the Prp19 Wdomainmain [8], [16] and is conserved as Cwf2 in S. pombe [24].
It cannot be due to an insufficient number of ORN axons to induce glomerulus formation, however, because we previously showed that over 30% of ORN axons must be removed before glomerulus number is decreased, while greater reductions, up to 88%, will decrease the number of glomeruli but not the distribution of the glomeruli within the neuropil.
Because we previously showed that Thr370 of CDK11p58 was responsible for CDK11p58 autophosphorylation, dimerization and kinase activity, mutant T370D and T370A were constructed.
The latter inhibitors are relevant to virulence because we previously showed that they inhibit the secretory pathway needed for capsule formation [ 32].
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Because we had previously showed that iNSPCs could contribute to poststroke neurogenesis and that cortical neurogenesis is related to the development of the iNSPCs, the effects of GITR Ab or GITR Fc on survival/death of iNSPCs were investigated by using immunohistochemistry for nestin and active caspase-3 on the ischemic brain sections.
Because we previously have shown that maternal levels of insulin, IGF-I, and leptin are decreased in rats fed a LP diet (20), it is possible that these endocrine changes contribute to the down-regulation of placental nutrient transport in response to maternal protein restriction.
We focused upon these three mediators because we have previously shown that receptors for these chemokines are highly expressed on inflammatory T cells from the joint in JIA [ 18]. mRNA coding for both CCL3 and CXCL10 was readily detected in both the inflammatory cells from the joint (SFMCs) of children with all subtypes of JIA studied and PBMCs from both patients and controls.
We chose to examine only HSB and LSB lines because we have previously shown that females show higher stress and anxiety-related behavioral displays than males in these lines [ 11].
We chose to evaluate HF patients, first because of the potential therapeutic relevance, and second because we have previously shown that in vivo arteriolar responses to nitrite are increased in patients with HF versus healthy controls (Maher et al., 2013).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com