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Because we previously hypothesised a peculiar involvement of RASSF1A in male fBC pathogenesis, we focussed on the MAPK and the Hippo signalling pathways that are regulated by RASSF1A.
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Based on the animal and laboratory evidence, we previously hypothesised that higher urinary BPA concentrations would be associated with adverse human health effects, especially in the liver and in relation to insulin, cardiovascular disease and obesity.
We previously hypothesised that men with asymptomatic infections/non-specific symptoms might be more likely to have prostate infection because of their likely lesser awareness of their STI and consequent delay seeking treatment.
We previously hypothesised that such metabolic alterations might quite possibly be more easily detected by an index summing up the contribution of individual MetS factors.
We had previously hypothesised that biofilms were better catalysts than planktonic cells for this reaction due to their enhanced viability in these reaction conditions, allowing the reaction to proceed for longer; however, flow cytometry reveals this to be untrue.
We have previously hypothesised that VAS amplifies the non-specific effects of routine vaccinations [ 10, 11].
We have previously hypothesised that t-PA concentrations are increased in response to vascular inflammation as a compensatory mechanism.
We have previously hypothesised that the protective role provided by the presence of neuroglobin could arise from its intervention in the mitochondrial pathway of apoptosis [ 12].
We have previously hypothesised that the bone loss seen in inflammatory arthritis is secondary to local glucocorticoid activation through the 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme [ 5].
8 We have previously hypothesised that periarticular osteopenia in RA is partly due to excessive local glucocorticoid activation through the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme.
We documented other cases where we identified genes previously hypothesised to play an important role in virulence but where current data were not conclusive.
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