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However, we did not exclude the involvement of the CIE pathway in hTAC endocytosis because we demonstrated that hTAC was internalized into EHD1-positive patch-like endosomal structures that were positive for other CIE cargoes but not the CDE cargo.
Because we demonstrated that GluRδ2 alone promotes the formation of PF synaptic contacts and PF presynaptic differentiation, we suggest that it generates PF-PC synapses in these compartments.
These time points were selected because we demonstrated that IDR-1002 altered IL-1β-induced cell signaling after 15 minutes of stimulation.
Our empirical data are highly valuable for advancing general understanding of evolutionary biology, because we demonstrated that robustness and evolvability can be positively correlated in a biological system.
This drawback was probably attributable to the ability of PPAR-γ to induce adipocyte differentiation [ 48], because we demonstrated that both TZDs stimulated the expression of adiponectin, a PPAR-γ-sensitive gene [ 49], in the adipose tissue of arthritic rats.
Because we demonstrated that the amino acid substitution caused by this polymorphism substantially impairs the ability of CFH to bind to MDA epitopes, our findings provide a direct connection between oxidative stress and AMD pathogenesis.
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This study has broader implications for ice sheet reconstructions and landscape evolution beneath ice sheets because we demonstrate that the primary control on fjord development in glaciated areas is geological and not glaciological.
However, these data should raise concerns for malaria control across Africa because we demonstrate that this level of resistance is causing operational failure of the insecticides used in LLINs.
7 Our findings are novel because we demonstrate that the magnitude of HS disease burden appears to be correlated with the risk of depression and morbid obesity, even after controlling for possible confounding variables.
Because it has been reported that BK causes tyrosine phosphorylation of endogenous EGFR in several kidney cancer cell lines, 19 and because in our previous work we demonstrated that BK-induced ERK activation in kidney cells was dependent on EGFR transactivation, 9, 10 in the next series of experiments we studied the role of EGFR in BK-induced ERK activation in A498 cells.
This was possible because we demonstrated with purified proteins that EIIANtr and P∼EIIANtr can be separated on non-denaturing polyacrylamide gels, with P∼EIIANtr migrating significantly faster than EIIANtr (data not shown).
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because we did that
because we worked that
because we took that
because we named that
because we knew that
because we thought that
because we used that
because we felt that
because we made that
because we played that
because we required that
because we spent that
because we saw that
because we met that
because we wanted that
because we had that
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com