Sentence examples for because this dose from inspiring English sources

For therapeutic purposes we used C60FAS in a concentration of 1 mg/kg because this dose was the most effective at muscular therapy [22, 23].

High dose IL-2 was avoided because this dose would stabilize Foxp3 expression [54], and thus mask the inhibitory effects of IL-1β and IL-6 on Foxp3+ Treg cells.

In preliminary experiments we evaluated recombinant human IL-18 at doses from 1 to 100 µg/mouse/day for anti-tumor effects in xenografted mice (data not shown), and 15 µg was chosen as a daily dose based on tolerability and efficacy, and because this dose is less than the equivalent maximum tolerated dose that has been established in monkeys and humans [25], [32].

Dose escalation to 240 mg BID in PM was terminated because this dose was not tolerated by the EM or the patients enrolled in the METIV-HCC trial.

The maximum dose permitted in this trial was olaparib 400 mg bid because this dose was determined as the MTD in a previous trial (Fong et al, 2009).

Cisplatin at 2.5  μM was chosen for future experiments because this dose promotes STAT1 activation and closely estimates the clinical plasma concentrations of cisplatin.

This genotype-specific improvement in attention in NK1R−/− mice is unlikely to be explained by a change in animals' state of arousal or motivation to respond because, at this dose, guanfacine did not affect the latency to correct response or the total number of trials completed by either genotype.

De-escalation to a lower dose level (60 mg m−2 wask−1) was not performed, because at this dose level a higher maximum tolerated dose could not be reached compared to the previous phase I trial in which a single dose of 240 mg m−2 (in a 4-week schedule) was the maximum tolerated dose (De Bono et al, 2000).

Incidents involving the continuous infusion of vancomycin, for example in the intensive care unit, were also excluded because this dosing regimen had been excluded from the FMEA discussions.

Experiments were carried out using 3 μM progesterone because: (i) this dose reflects concentrations in follicular fluid and the cumulus oophorous [ 39]; and (ii) in our previous imaging and fluorimetric studies, this concentration fully saturated the high-affinity [Ca2+]i response but did not recruit a low-affinity receptor response [ 40].

Because of this dose-dependent removal, the LDH assay for cells exposed to silver nanoparticles was considered suspect, although at the low doses applied at the ALI the LDH assay may not be strongly affected by the silver nanoparticles.