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We used HeLa because they express high levels of both eEF1A isoforms, eEF1A1 and eEF1A2.

MKN-45 cells were selected because they express high levels of MMP7 and low levels of miR-148a.

UM-SCC-1 cells were selected because they express high levels of VEGF but have undetectable levels of VEGFR1 or VEGFR2.

The HEK-293 cells were selected because they express high levels of the β-tubulin and CCT- β proteins (Supplementary Figure 1) and are thus highly sensitive to I-Trp.

MCF-7/MR cells were used in this study as control because they express high levels of BCRP and are highly resistant to BCRP substrates such as MR and methotrexate (Maliepaard et al, 2001; Ifergan et al, 2004).

The MDA-MB-231 cells were chosen not only because they express high levels of COX-2, but also because they differentiate into tubular structures within 2 hours of plating on matrigel and form well defined vascular channels by 7 hours.

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Growing endothelial cells at sites of angiogenesis may be more sensitive than quiescent endothelial cells to toxin-VEGF fusion proteins, because they express higher numbers of VEGF receptors.

Although naïve T cells also express CCR7 and IL-7R and do not express granzyme B, the CD62L+ B8R20–27 pentamer+ cells are unlikely to be naïve cells because they expressed high levels of CD44, IL-15R and IL-18R (Fig. 3a, b) and NKG2A (data not shown).

However, because they expressed high levels of MHC molecules and costimulatory ligands as well as their ability to take up antigen in the infected respiratory tract, the CD103+ and CD11bhi RDC also had the potential to serve as APC after their migration to the draining MLN (Fig. 2C).

Adolescent animals were chosen because they express a high amount of α6 mRNA relative to adult animals.

HeLa cells were chosen because they express relatively high levels of endogenous IFITM3 and differing endogenous levels of IFITM3 strongly correlate with AmphoB's effects on IAV replication (Feeley et al., 2011; Roethl et al., 2011).

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