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Eukaryotic tumors contain many clonal mutations, i.e. mutations that are present in a proportion of tumor cells and on which selection occurs because they confer a growth advantage.
A possible explanation is that de novo structural aberrations arise frequently, and in most cases disappear from the rapidly proliferating population because they confer a proliferative disadvantage.
The simplest structure of neo-Darwinian natural selection has just two parts: 1) random variation of traits results from random mutation of genes and through sexual recombination; 2) some traits spread because they confer a reproductive advantage.
Tens of S-haplogroups with high sequence divergence are maintained within populations by frequency-dependent selection, because they confer a minority advantage (Castric et al., 2008; Llaurens et al., 2008).
The discovery of amino acid-modified V. cholerae lipid A revealed an interesting link between Gram-negative and Gram-positive cell surface modification systems, not only because the molecular pathways are remarkably similar but also because they confer a shared phenotypic outcome leading to polymyxin resistance.
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As mentioned earlier, the transferred genes are fixed in genomes probably because they confer an evolutionary advantage to the host.
Polymorphisms that arise independently multiple times are of interest since they may represent genetic changes that are under evolutionary selection because they confer an advantage to the organism.
Instead, as several of the amino acid changes (50, 133, 174, 176) were associated with reversion toward a consensus-B like viral sequence, it is possible that many amino-acid changes throughout the Nef sequence were selected for because they conferred an increase in viral fitness.
Extended-spectrum beta-lactamase (ESBL -producing strains of ESBL -producingreprestrains a small percentage (<10%), are particularly cofcE.ning becolie they confer resistance to a myriad of antibiotics including penicillins and third generation cephalosporins, and because their prevalence has been increasing in community and hospital settings during recent years [ 2, 3].
People inherently like beautiful things, Ms. Postrel writes, not because they confer status or because a magazine has told them to look a certain way, but because it makes them feel good.
Lignins play an important role in trees because they confer rigidity and impermeability to wood by accumulating in thickened secondary vascular tissues [ 1, 14], therefore its regulation is of interest for understanding the genetic basis of wood properties.
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