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The genes were selected because their expression affects 5-HT activity and closely-related neural functions and they have previously been reported to be associated with a diagnosis of ADHD.
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The researchers then checked out skin samples and found that there were several proteins that had their expression affected in every volunteer's case.
How is their expression affected by environmental factors?
On the other hand, the use of reporter genes often fails to accurately detect chimerical tissues because their expression can be affected by several factors, including gene silencing and plant development.
Because Lck expression affects T cell activation and proliferation after TCR engagement, it is reasonable to hypothesize that the Lck upregulated during imatinib treatment decreases the threshold of T cell activation and to some extent may enhance T cell activation, proliferation, and cytokine production.
Because decreased Myomegalin expression affects MTs originating from the GA in RPE1 cells we wondered whether cell mobility was altered.
It's believed that α-synuclein null mice are protected against MPTP intoxication because lack of α-synuclein expression affects a yet to be defined process that occurs post uptake of MPP+ into the terminal and pre-mitochondrial complex I inhibition [42].
In hematopoietic cells, expression of pc-Mybex9b accounts for 10 15% of total c-Myb; these levels may be biologically relevant because modest changes in c-Myb expression affects proliferation and survival of leukemic cells and lineage choice and frequency of normal hematopoietic progenitors.
These genes were chosen because in our previous study we found that their expression was affected by the combination of sucrose plus starch [16], and are both relevant for biofilm formation (EPS-matrix synthesis) and physiology (intracellular sugar metabolism).
Expression of ACTB and TAF5 was not affected because MAF1 and Pol III did not bind to their promoters and their expression was not affected by MAF1 knockdown; therefore, they were used as negative controls.
Genes that were closely linked to each other become separated and vice versa; this can affect their expression because genes are often transcribed sequentially, two or more at a time (see heredity: Linkage of traits).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com