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Over time, our self-esteem may plummet because the validation is in a sense, artificial and only skin deep.
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The validation is credible because it comes from an independent, third party that has evaluated your product relative to your competitors.
Differences in vd for the various validations could be expected because the validations were carried out over longer or shorter periods of time and during a time period of 3 years.
This type of analysis is prone to model overfitting and is nowadays increasingly regarded as only hypothesis-generating because the important validation is missing.
"We will release more publications in the future, because validation is very important," Poh says.
It should also be noted that there must be many additional DEGs in the 36 experimental datasets because the RT-PCR validation is performed only for a subset of top-ranked genes.
However, if the nearly perfect sensitivity and specificity values attained were only due to this fact and not to the suitability of the extracted features to be employed as tissue markers, near-perfect classification would also have been attained with textural features because the cross-validation is also performed across the same training and validation sets.
Because validation is often laborious and incomplete, it may be more efficient and informative to deploy two sequencing methods fully and independently.
Because validation is an ongoing process, it is imperative that its use be evaluated by independent groups of caregivers who were not involved in its development, with various ICU patient groups or with a translated version of the scale.
Because validation is often a secondary study aim and therefore not highlighted in titles, abstracts, or keywords of papers, even a comprehensive systematic search cannot identify all relevant papers.
Demonstrating equivalence to the traditional method during validation is simplified because the new technology provides numerically equivalent results in the same units (CFU).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com