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Because the upper confidence limit of the control sera is less than the MDC (0.06 µg/mL) of the assay, the MDC of a 1/50 diluted serum becomes the default reactivity threshold and corresponds to an anti-PA IgG concentration of 3.0 µg/mL in an undiluted serum sample.
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In either of these cases, the upper confidence bound may be considered an upper limit.
The upper confidence level is 1 - α = 0.95.
In this figure, the red dotted line represents the upper confidence limit of the ACF values.
Interestingly, the upper confidence limit indicates a very recent increase in population size.
The seroconversions in February 2012 were above the upper confidence limit for prediction of the proportion of seroconversions for February 2012 (6% vs 2% as the upper confidence limit).
The upper confidence limit is the value of the larger root.
Data for octaCDD scattered in some cases distinctly above the upper confidence limit.
When only a single root is found, we set the upper confidence limit to infinity.
Thus, despite a statistically significant difference of 0.17%95%5% confidence interval: 0.03% 0.30%) in HbA1c reduction, noninferiority was claimed because the upper limit confidence interval for the estimate did not exceed the noninferiority margin of 0.4%.
The assay cut point was derived from the 95% upper confidence limit after removal of outliers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com