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Exact(11)
In this particular case, it is especially wrong, because the two genes would likely have been isolated ("discovered," in Myriad's terminology) soon anyway, as part of the global Human Genome Project.
The human heterozygosity value at the level of proteins is stated as H = 0.067, which means that an individual is heterozygous at 6.7 percent of his genes, because the two genes at each locus encode slightly different proteins.
The authors believe that the Notch and Distal-less signaling pathway arose after the evolutionary split between moths and butterflies, because the two genes were not expressed in two unpatterned species of moth they studied.
Because the two genes that determine G-types and P-types can be passed on separately to progeny viruses, different combinations are found.
Differential regulation of hmsT and y3730 transcription does not appear to account for the different in vitro and in vivo phenotypes, because the two genes were transcribed equivalently in both environments, with the expression of both being upregulated in the flea (Fig. 4).
Because the two genes are transcribed in opposite directions, it is possible that the 1.4-kbp intervening chromosomal region contains regulatory elements that control both genes.
Similar(49)
Eventually, some incipient reproductive isolation may take effect because the two gene pools are no longer adapting in concert.
Because of this, the two genes share a regulatory structure, which can serve to correlate noise in toxin and antitoxin expression.
This contention, however, is rather unlikely, if not impossible, because one of the two genes for the same function, in general, would have easily been lost during evolution, while IF1 is well conserved from yeast to humans.
Intuitively, we see that the synergy of the hypothetical genes in Figure 1A is negative, because of the underlying redundancy (each gene is sufficient by itself to determine if there is cancer), while the synergy of the genes in Figure 1B is positive, because the combination of the two genes is required for such determination.
However, one of their candidates, ZNF649-ZNF577, was removed by our conservative homology filtering step, because we found that the two genes share a region with 42 matches in a window of size 50.
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Justyna Jupowicz-Kozak
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