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The methodological quality is poor because the statistical method applied is not appropriate to test the hypotheses.
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The symptom outcomes and tolerability outcomes are less vulnerable because of the statistical method used.
It is important, however, to note that our results might be affected by differences in PPD or BOP between smokers and non-smokers, because of the statistical method we used.
The PO banding, based on Poisson distribution, inappropriately indicated too many trusts to be performing outside the expected range because the statistical methods did not account for the substantial unexplained variation in the statistical model, a phenomenon known as overdispersion.
The high prevalence rate reported in this review has to be interpreted with caution because the authors did not specify the statistical method that was used to calculate the aggregate prevalence.
In many papers, it was difficult to assess whether the statistical analysis was appropriate because information detailing the statistical methods was lacking.
Note that the original publication reporting analysis of gene signatures and treatment response [ 19] has since been retracted because of concerns regarding the statistical methods used to generate predictive models (see Lancet Oncol 2011, Feb; 12 116 and Lancet Oncol 2010 Sep; 11 813-814).
Stepwise logistic regression was used to create final multivariable models for each of the three outcomes as described in the Statistical Methods; because plasma HIV viral load, cervical HIV viral load, and CD4percentt were collinear, we adjusted for these in separate models.
All the statistical methods were used because of the methodology of exploratory research where the use of the subsequent analyses is dependent on the previous outcomes.
The statistical methods used were chosen because they are appropriate methods to analyse the differences between the groups.
"The statistical methods are shoddy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com