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This could potentially affect current established exposure levels for humans, because the reference dose for ESF of 0.02 mg/kg/day is based directly on the rodent NOEL of 2.0 mg/kg/day.
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Interestingly, while Sushi Yasuda, the midtown shrine to raw fish, had a relatively high mercury level of 0.79, it would take 9.9 pieces to reach the reference dose.
Hg consumption limit calculations were based on the reference dose (RfDo) set by the US-EPA.
However, estimated dose for, Heptachlor epoxide, Dieldrin, Endrin and Aldrin exceeded the reference dose and were higher than toxic threshold indicating a potential toxicity in humans.
The reference dose was chosen based on previous studies that showed strong inflammatory and genotoxic responses following instillation of this dose of NPCB and because we routinely include NPCB as a benchmark exposure [Saber et al., 2011a, b, 2012].
The low dose was one-fiftieth that of the U.S. EPA reference dose (U.S. EPA 1993), and the high dose was 2 times higher than the reference dose.
The reference dose (refi) can be, for example, the acceptable daily intake, ADI.
The reference dose is defined in accordance to the International Commission on Radiation Units and Measurement report 50/63.
The reference dose (RfD) is 20 μg/kg/day according to the U.S. EPA.
Daily exposure doses of Cr, As, and Cd were all below the reference doses.
Because these doses are below the current reference dose, this finding received a considerable amount of attention.
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