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Because the reference design has a smaller SWISS score of 0.94, we conclude that the reference design is significantly better at clustering the data of different ER status (positive vs. negative) than the single channel design.
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Additionally, there is an effective doubling in measurement error by the reference design because every ratio includes error contributions from both experimental and reference channels [16], [19].
Because the SWISS score of the reference design is smaller than the perfect-feature enhanced SWISS score of the single channel, we conclude that the difference in SWISS scores between the single channel and reference designs of dataset I is not only statistically significant but also biologically meaningful.
We opted for the reference design, because it is robust to bad arrays, amenable to clustering and, more importantly, allows for comparison of more than 2 classes (time points) at once, without dye effects [ 60].
As previously noted, we may have been comparing different gene sets because the most variable genes in the reference design did not necessarily coincide with the most variable single channel design genes.
Because both p-values are less than 0.05, we conclude that the reference design is significantly better than the single channel.
Always the reference design, never the retail unit.
"It's following the reference design and the reference design has a given set of specs and features," Hugo Swart, a product management senior director at Qualcomm tells me.
The reference design that'll be shown will carry an MSRP of just $199.
The PEP, the Baxley, and the proposed design outperform the reference design.
Because the p-values of the reference and single channel designs are both 0.26, we conclude that there is no significant advantage to using the reference design over the single channel design.
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