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Because the protocol design focused on velaglucerase alfa safety rather than on treatment efficacy, information on the preenrollment duration of imiglucerase interruption or dose reduction was not collected.
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First, in the overall study population, the timing of the first adalimumab dose was not the same for each patient because of the protocol design.
However, the protocol design of this kind of protocols is the most complex because a series of problems are needed to be considered, such as synchronization mechanism and slot allocation strategy.
YS supervised the protocol design.
All authors contributed to the protocol design.
FC aided in the protocol design.
This paradoxical aspect may because the different protocol designs on image scanning location, age and BMI.
However, antisense RNA detection was limited in that study, because the protocol was designed to preferentially detect short RNAs.
It will also aid in the initial protocol design for the pilot study.
Figure 1 shows the study protocol design.
It also limits the applicability of clinical research to large segments of the oncology population because protocol designs tend to exclude older and sicker patients [ 21, 22].
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