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Exact(6)
But because the mutations are so rare, costly studies involving large numbers of patients would be needed to identify their role in each disease.
"Normal" users may not even know that the software they are using is different from the software used by the person in the neighboring cubicle because the mutations are neutral with respect to the standard program behavior.
Molecular analysis would confirm hereditary hemochromatosis, but it has a variable diagnostic sensitivity because the mutations are different in different geographic areas.
Because the mutations are familial and are carried on single haplotypes, it is unlikely that unreported polymorphisms under the PCR primers or the probes will affect the analytical sensitivity or specificity of the assay.
We reasoned that the PTC27 and PTC140 transcripts were not affected probably because the mutations are too far from the intron the PTC27 transcript is more affected than PTC140 most likely because it is more sensitive to splicing-independent NMD, like we have seen for mRNAs that have not undergone splicing.
However, because the mutations are in the terminal exon and are unlikely to result in nonsense-mediated decay of the mRNA, and because patients are comparable in severity to the Canadian-null patients, it is also possible that the mutant protein causes a dominant negative effect.
Similar(54)
And because most of the mutations are rare, they are extremely hard to find.
Because most of the mutations are transitions, p53 mutations in these cancers likely arise from spontaneous errors in DNA synthesis and repair rather than from exposure to carcinogens.
However, this scenario would seem less likely, in particular because none of the mutations are greatly destabilising per se.
Although the mutations are rare, because of their deleterious effects on reproduction, they have been elucidating by unraveling several poorly known aspects of gonadotropin action.
The observed mutations in the cDNA from tumor cells were not created by RNA editing because the mutations were detected also on genomic DNA level.
More suggestions(15)
because the cancellations are
because the times are
because the transformants are
because the Muppets are
because the mutations make
because the films are
because the mutations lie
because the terms are
because the Scots are
because the terrorists are
because the bracelets are
because the pontificators are
because the rules are
because the talks are
because the risks are
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com