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Because the metabolite pattern changes during pregnancy (Concha et al. 1998b), all pregnant women (from 1997 from 2004, and 2005) formed a separate group (n = 37).
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It regulates the metabolite pattern of higher plants and changes metabolite concentrations in plant tissues (Marschner 2012).
In Bangladesh, all AS3MT polymorphisms except rs7085104 were significantly associated with the metabolite pattern.
We therefore evaluated the influence of U-As on the arsenic metabolite pattern in this population.
We found three strongly linked intronic SNPs in AS3MT that significantly affected the As metabolite pattern.
Two haplotypes, 2 and 4, were significantly associated with the arsenic metabolite pattern (Table 3).
For example: "This finding suggested that the observed metabolite pattern characterized cumulative damage".
This indicates that the secreted metabolite pattern alone is not sufficient to determine which specific production and secretion pathways are used by the cell for these metabolites.
Because such uncertainties would invalidate the urinary arsenic metabolite pattern as marker of arsenic methylation efficiency, we decided to include only individuals with total urinary arsenic metabolite concentrations >5 μg/L (N = 285) in the genetic association analyses.
ANOVA of the cross-validated models were used to determine the significance of the extracted metabolite patterns.
In the analysis of metabolite pattern, we combined haplotypes that were significantly associated with arsenic metabolites.
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