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Such proteases may have interesting developmental functions because the expression patterns of several are highly regulated along the primary axis at times when cell differentiation and morphogenesis begin.
However, because the expression patterns of dorsoventral patterning genes are not entirely consistent between Cnidaria and Bilateria, the molecular data do not make clear whether one side of the directive axis corresponds to the dorsal of Bilateria, and the other side to ventral.
Because the expression patterns observed in many GOs were difficult to interpret in terms of functional change, we turned to investigate expression changes in the superoxide detoxification pathway, a well-defined cellular function that declines with age (Ashburner et al., 2000; Mi et al., 2005; Kumsta et al., 2011; Bansal et al., 2015; Rangaraju et al., 2015a).
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An exclusive transcriptional link is unlikely because although the expression patterns for the two proteins were similar throughout the ear they were not identical and PKBβ/Akt2 was clearly expressed in groups of cells that lacked gata3.
One may raise a concern about the use of fibroblasts as a model because the expression pattern of this molecule has been thought to be restricted within leukocytes.
We chose Muc1 and Muc4 because the expression pattern of these mucin genes overlapped with Muc16 and Muc16 mRNA levels are increased in the lung of Muc4 knockout mice [26, Wanda O'Neal, personal communication].
Because the expression pattern of SLC30A8 is so anatomically restricted, it will be challenging to assess for such variability in mRNA expression in vivo; pancreatic biopsies will likely not be undertaken for this purpose, and post-mortem examination may be confounded by the effects of years of diabetes.
However, the prg-1 mutation did not affect the 26G-RNA-mediated pathway because the expression pattern of the 26G-RNAs did not change.
The discrepancy occurs because the expression pattern of most genes is primarily affected by the tissue and not so much by sex or breed, as discussed.
Comparing these datasets is not straightforward because the expression pattern descriptions can be taken to different resolutions by the different methods.
The expression of the ENOD genes was down-regulated all together by the three stresses because the expression pattern of the ENOD transcriptional regulators ERN and NSP were altered by these stresses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com