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In fact, both updates in (8) and (9) may be as small as zero because the error rate usually is quite small compared to the other quantities.
Finally, because the error rate in GA sequences increases towards the end of the sequences, we also plotted the distribution of the identified SNPs against the nucleotide position within the GA sequences (Figures 1, 2).
However, it should be noted that M184V was observed, but the levels of this mutation were not above the statistically derived cut-off value, because the error rate was comparably high for this mutation (median cut-off value 0.17%) (Table 2).
Because the error rate of genotype calling is less than 1% [ 17], the missing rates were 0.1%, 0.5%, 1%, and 5%.
According to this argument, the asymmetry of the rows and columns arises directly because the error rate at second position is smallest.
This is because the error rate was so high, and the base quality values are so poor that the mapping quality scores were always extremely low.
Similar(48)
Then, we show that the ordering of sibling points must be the same in each interval, because otherwise the error rate increases.
Currently selection of subclonal mutations in cancer is difficult to prove outside the coding regions of known cancer drivers, in part because the error rates of existing NGS platforms limit detection of single-nucleotide allele frequencies to >1%.
For several frames, prediction accuracy is not so high thus error correction does not work well because the error rates exceed the correction rate of the channel coder.
Such ambitious targets are feasible because the error rates of proofreading DNA polymerases are lower than 10 6.
A further reduction could be obtained by determining the correct position of markers for which the locations had only been estimated because the error rates were higher for markers with estimated positions.
More suggestions(15)
because the recurrence rate
because the reward rate
because the detection rate
because the mortality rate
because the growth rate
because the inflation rate
because the burn rate
because the interest rate
because the response rate
because the vacancy rate
because the error error
because the tax rate
because the survival rate
because the error cost
because the exchange rate
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