This is remarkable because histone encoding genes are typically expressed in early HSC, suggesting a shift towards a more differentiated phenotype of CD34+ cells in CAD patients [ 15].
To gain a deeper insight into the function of the identified phosphatases, we attempted to construct null mutants for the 31 phosphatase encoding genes (because A. fumigatus calA gene encoding the catalytic subunit of calcineurin has already been deleted) (Steinbach et al. 2007; Da Silva Ferreira et al. 2007).
We originally analyzed the expression of platelet-derived growth factor because the genes encoding the A and B chains of this growth factor are mapped to chromosome regions 7p22 and 22q13.1, respectively.
ENO1 has been shown to be homozygously deleted in certain glioblastomas, probably as a passenger event to the deletion of ERFFI1, but the tumor cells are able to survive because of the activity of other enolase encoding genes, in particular ENO2.
Additional lactic acid feeding was necessary for growth because the genes encoding the PEP consuming pyruvate kinase isoenzymes have been deleted.
At the same time, high Pi concentrations may inhibit plant growth because the genes encoding many nuclear proteins, such as poly(A) polymerase (e.g., Os06t0558700), many protein synthesis-related proteins, such as translation initiation factor 2 (e.g., Os03t0296400) and aminoacyl-tRNA synthetases (e.g., Os06t0645400) were downregulated in shoot.
The early attempts to enhance Al tolerance focused on OA synthesis because the genes encoding transporters for OA anions were not cloned at the time.
Convergent evolution is also the most likely mechanism for generating the sequence similarity between avian EDCRP and mammalian KRTAPs because the genes encoding EDCRP and KRTAPs are very likely to have different evolutionary origins.
Because the genes encoding the other four steps of the l-arabinose pathway in T. reesei are represented by ESTs in the NCBI database, we also tested if our potential LXRs are present in this EST database.
Because the genes encoding these enzymes are separated by only ∼20 kB, our mice lacking group V sPLA2 are also deficient in group IIA sPLA2 (Supporting Information Fig S5 and Table 1).
