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Staunton proposed and then took the lead in organising the first ever international tournament, as he thought the Great Exhibition of 1851 presented a unique opportunity, because the difficulties that obstructed international participation would be greatly reduced.
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"Because of the difficulties that were being experienced with the communications system there on the day [in 1989], I would have thought that should remain in," he added.
The finite element simulation of nesting phenomena in textile composites is challenging, because of the difficulties that come with creating a 3D finite element model of a stack of nested plies.
The numerical approaches have been used in many studies to predict the flow pattern inside the bubble column reactors because of the difficulties that are still found in designing and scaling-up the bubble columns.
However, this is a common limitation in signal detection research because of the difficulties that accompany building a 'reference standard' and the long time needed to gather data prospectively.
This controversy has been generated in part because of the difficulties that are presented to the clinician when substitutions for β-blockers need to be made before the initiation of immunotherapy and because in some instances immunotherapy can be carefully performed even in patients who are receiving venom while on β-adrenergic blockers.
Another mediator, María Emma Mejía, said, "Substantive advances had been made, and I am surprised, because getting past the difficulties that remained was possible".
Yusuf decided to leave Nigeria because of the difficulties that people with disabilities face there.
Flu vaccinations have been delayed around the nation this year because of the difficulties that other companies had in making the vaccine.
At a news conference following the event, Mr Robinson joked that it was good to talk to Mr Cameron because he understood the difficulties that can exist in coalition governments.
The controversy surrounding the role of HPV in breast cancer may be because of the difficulty that has been encountered in detecting the virus in breast specimens, in contrast to the relative ease of detection in cervical cancers (Lindel et al, 2007; Khan et al, 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com