Missing data or incomplete sequences did not, however, affect the inferred phylogeny because the dataset in our study provided sufficient information, consistent with previous empirical studies [22], [31], [32].
Because the dataset in this study was derived from an insurance claim database and the data conform to the Health Insurance Portability and Accountability Act of 1996 confidentiality requirements, the study did not require informed consent or institutional review board approval.
However, these results do not exclude a role of TEs in microgeographic adaptation because the dataset analyzed in this work is restricted to TEs identified in a single North American strain and as such is highly biased and incomplete.
There is no fixed taxonomy of OSM data, because many people contribute to the dataset in a joint effort.
Because the dataset used in this study consisted of deidentified information for academic research, the IRB waived the need for informed consent from the enrolled patients.
Because the dataset used in our analysis consisted of shotgun sequences providing a 0.66× coverage, the sequence redundancy in our dataset is limited.
Informed consent of the study participants was not required because the dataset used in this study consists of de-identified secondary data released for research purposes.
The IRB waived the need for informed consents (written and oral) from the patients because the dataset used in this study consists of nationwide, unidentifiable, secondary data released to the public for research.
However, gene expression profiles present many challenges for data mining both in finding differentially expressed genes, and in building predictive models because the datasets are highly multidimensional (12,600 dimensions in our study) and contain a small number of records (197 records in our study).
Unfortunately, some of this poor agreement might be due to temporal changes in the Black Sea, because the datasets being compared were not obtained contemporaneously.
