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Because the computational modeling of heterogeneous conformational ensembles from experimental data is an open problem (Beauchamp et al., 2014; Salmon et al., 2014; Shi et al., 2014), our primary conclusions below are based on the M and MOHCA-seq data themselves, with Rosetta modeling carried out for initial visualization only (see 'Materials and methods').
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S.A. led the computational modeling, and U.P. performed the study on the Cu+ diffusion in CdSe.
The computational modeling was supported by the US DOE Office of Science (DOE DE-SC0012547).
YY performed the computational modeling.
CT and BSG conducted the computational modeling.
The possibility that recurring selection may be reducing viral diversity is unsettling because most of the computational models used to estimate N e assume neutral evolution.
No restriction is placed on the type and representation of the computational model because Mudi operates directly on timeseries data.
First, the computational model is based on adult cardiac electrophysiology, because, at this time, appropriate models have not been developed for infants.
O.S.V. and M.T. performed the computational modelling.
S.B. designed and conceived the computational model.
T.J.G. and Y.G. performed the computational modelling.
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