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However, the comparison remains fair if we assume L at least equal to n R because the computational burden is on the inversion of the covariance matrix.
With tens of thousands of SNPs from thousands of samples, it is difficult to calculate higher-order interaction exhaustively because the computational burden is too heavy.
BLUP is suited for handling a massive amount of genetic information, because the computational burden can be proportional to the number of data points rather than the number of predictor variables (e.g., markers), and this is particularly true if a common weight is assigned to a each marker.
For a union of k markers, the union test is approximately k-1 times faster than the corresponding single marker test, because the computational burden of taking the union is less than the computational burden of performing one Fisher's exact test.
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However, because of the computational burden, hourly computation is often simplified in actual designs by rules of thumb or approximations that can cause over- or under-design of the GLHE system.
The 3D elastic problem has not been widely studied because of the computational burden.
We did not use the entire dataset to carry out parameter selection because of the computational burden.
However, this is only feasible for a limited number of SNPs because of the computational burden in calculating the probabilities from a large-dimensional MVN.
First, because of the computational burden, it would have been prohibitive to consider the joint distribution at two chromosomes after blocking.
Epistasis is a fundamental component of complex trait variation that may be an important driver of adaptation, but such effects are difficult to quantify because of the computational burden of testing all possible pairwise interactions for hundreds or thousands of loci (Phillips 2008).
Because this model drastically lowered the computational burden of simultaneous alignment and folding, it has been adopted by many successful RNA alignment approaches.
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