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Therefore, it could be inferred that this catalyst is becoming less stable at higher temperature and increasing NBE concentration reduces the activity primarily, because the active site gets blocked with NBE.
ODC activity requires dimer formation because the active site in each monomer is formed by the interface between the N-terminus of one monomer and the C-terminus of the other subunit [43] [47].
All of these changes in either the F13 or Y79 do not affect the bypass fidelity in MMS, presumably because the active site is flexible and adapts to the different lesions.
We argue this may be because the active site of an enzyme requires unusual properties with respect to the rest of the protein, for example, many active sites (including the current example provided here) comprise deeply protected clefts which may be required for interaction with substrates that include substantial hydrophobic patches.
Two of these homologues, calpamodulin and androglobin, are not peptidases because the active site cysteines have been replaced [ 5, 6].
Besides peptidases, family A1 also contains a number of proteins which cannot be peptidases because the active site aspartates are not conserved.
Similar(43)
This is because the active sites are composed of Cr O Ce species.
Because the active sites are located on the inner surface of the micrometer-scale channels the performance degradation caused by peeling, aggregation, and crack during operation can be avoided, resulting the high stability.
Because the active sites of TIM barrel enzymes are invariably comprised of the loops protruding from the C-termini of the β-strands, engineering βα-hairpin clamps at the N-termini of the β-strands offer a unique opportunity to enhance the stability of TIM barrel proteins without compromising function.
Achieving high isoform selectivity has been a challenge because the active sites of all three NOS isoforms are very similar.
Because the active sites of PAD2 and PAD4 are similar, 2CA can bind to both thereby inhibiting citrullination totally (see PAD2 knockout described above).
More suggestions(17)
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