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Finally, the reported research to date on the effect of GoF patterns on software quality attributes are controversial; because some studies identify one pattern's effect as beneficial whereas others report the same pattern's effect as harmful.
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This may be because the studies identified are predominately from the USA.
However, this theory is controversial because several studies identified an increase in empyema prevalence before the introduction of PCV7 (5, 21, 22 ).
The 1p36 region is believed to harbour tumour suppressor genes, because previous studies identified frequent allelic imbalance at 1p36 in various types of human cancers (Schwab et al, 1996).
The Downs and Black tool (Table 2) considers 5 assessment domains, but because most observational studies identified were primarily descriptive, we excluded the power domain in this review.
Because there were no studies identified that formally evaluated D/SD compared with DF/DHF/DSS in these areas, we refer to the discussion section below, where expert opinions/viewpoints were also included.
Meta-regression was not attempted because of the small number of studies identified.
Fourth, we did not search for non-published studies because of the large number of studies identified.
However these could not be explored in this analysis because of the limited number of studies identified.
Minor deviations from the published protocol were made in data extraction procedures because of the large number of studies identified by the review.
We could not explore the sources of heterogeneity by conducting subgroup analyzes or meta-regression because of the small number of studies identified.
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