Because some earlier studies [5], [7] concluded that previous BCG vaccination does not influence the assay performance we wondered whether HBHA-based methods would retain their diagnostic potential also in Finland.
Longer periods of observation can increase the number of patients with clinically relevant or subclinical signs of nephropathy, because some earlier studies have shown that frequency of nephrotoxicity after chemotherapy increases with longer time of followup.
However, due to limitation of resources in this study, only papers published in English were reviewed and this may lead to a reporting bias because some early clinical studies on the use of SDF were conducted in Japan and in China [ 35].
However, to date, little attention has been given to develop host-based prophylaxis aimed at selectively eliciting apoptosis in infected cells, perhaps because of early studies demonstrating that infected cells could resist apoptosis.
It [once] made a lot of sense that dietary cholesterol might be an important factor in heart disease risk because early studies — the Framingham [ Heart Study was one of the first — showed that blood levels of cholesterol are strongly predictive of heart disease.
One problem with the current study, according to Sicherer, is that it does not necessarily address the question of "reverse causation". "Mothers of infants [might] have been told that breastfeeding [protects against allergies] because early studies showed that compared to having formula, infants [who were] breastfed had [fewer] allergic skin rashes and milk allergies," he said.
Because early studies on local adaptation [e.g. 32] [35] either did not reciprocally transplant between sites, did not report the data required for meta-analysis, or because it was not possible to inquire further information from the authors, they could not be included.
A gentamicin trough concentration of <2 mg/L is usually recommended because early studies reported an increased risk of toxicity with higher concentrations [ 23].
Hospital stay has mostly been investigated with consecutively admitted inpatients irrespective of diagnosis perhaps because early studies showed that diagnosis is not associated with LOS [ 11, 12] an issue which remains controversial.
