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Because profound differences between the orthologs in the susceptibility to inhibition were observed, we also analyzed (iii) if molecular docking experiments performed with modeled enzymes can differentiate or predict the efficacy of inhibitors.
We targeted adolescence because profound developmental changes in the brain reward system occur during this phase [7] [9] and, concomitantly, the consumption of sugar in humans is highest during this period of life [5], [6].
HIV-1 co-infected patients may be at increased risk of acquiring nosocomial drug resistant pathogens because profound immune suppression results in co-morbid illnesses that require prolonged inpatient admissions.
Data from the Guyana sugar plantations must include factors other than DDT and malaria because profound differences existed in all-cause mortality in adults and children over the span of the reports.
Not surprisingly, in the parous group from Figure 1A, mice with pSTAT5lo and pSTAT5hi baseline levels (same criteria as in virgin mice) had similar tumor latency (data not shown), probably because profound STAT5 activation during pregnancy and lactation masks the effect of baseline pSTAT5 variations among individuals.
Because profound and persistent hypoglycemia with MK-0941 potentially mediates cataract formation in animals, the present results suggest that the mild-to-moderate, transient episodes of hypoglycemia and rare incidence of severe hypoglycemia reported with MK-0941 in this study would not be expected to lead to clinically meaningful eye-related changes.
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I found that profound, because often, we hear about black people having a particular aversion to the LGBT community.
Monitoring and control of emulsion polymerization reactors presents several difficulties because of profound modeling limitations and on-line measurement problems.
Two patients had cerebral ischemia secondary to hypotension because of profound bleeding, with intracranial hemorrhage in 2 additional patients.
Legislation to set federal privacy standards died this year because of profound disagreements between consumer advocates and the health care industry.
Because his profound deafness prevented his own performance of the solo part, the honour fell to a 25-year-old church organist, Friedrich Schneider.
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