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Because our data suggest that GCSF impacts IRF8 levels, we analyzed the impact of Flt3L and anti-GCSF IgGs on IRF8 levels in DC progenitors.
Birnbaum is on to something when he talks about getting employees to "collide," because our data suggest that creating collisions chance encounters and unplanned interactions between knowledge workers, both inside and outside the organization improves performance.
This may be an important point because our data suggest a temporary rise in serum creatinine during the first hours after successful cardio-pulmonary resuscitation.
Because our data suggest that Hausp inhibition and AMPK activation each destabilizes nuclear Cry1, we examined whether they could synergistically increase circadian period.
Because our data suggest that OA chondrocytes may be particularly sensitive to oxygen, the different oxygen levels could explain the discrepancies.
Because our data suggest that the cholesterol-lowering effects of rmFGF21 are independent of adiponectin, we further explored the mechanisms by which FGF21 modulates cholesterol metabolism in mice.
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Because our data suggested that the pro-apoptotic function of G-Rh2 might largely depend on the up-regulation of Fas and TNF-R1, we examined the Fas or TNF-R1-mediated caspase-8 activation cascade by, respectively, silencing Fas or TNF-R1 via using small interfering RNAs against them in HeLa cells.
Because our data suggested that Hydralazine causes Rasal1 de-methylation through a mechanism involving Tet3-mediated hydroxymethylation, we next elucidated the involvement of additional factors which are involved in replacement of hydroxymethylated cytosines with naked cytosine bases.
Because our data suggested that the reconstitution potential of wt HSPCs is limited by Bim-dependent apoptosis under conditions of reconstitution stress, we transplanted rate limiting numbers of wt or bim −/− BM-derived cells simultaneously with 200,000 Ly5.1+ BM competitors.
We decided to include gender, grade-level, and BMI in one analysis, because different authors have discussed interactive effects of gender, weight, and age and, moreover, we wanted to account for confounding effects because our data suggested associations between the factors.
Pump settings are normally altered infrequently and, because MCR is reproducible, our data suggest that the overnight plasma insulin concentration in pump-treated patients is consistent between nights and unable to explain considerable night-to-night blood glucose variations often observed in T1D.
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