Unlike the initial DNA damage, no conclusions could be drawn about the influence of previous RT on the residual DNA damage and repair half-time, mainly because of the wide individual variability of these parameters.
There is no normal value of O-C2a because of the wide individual variations, and O-C2a does not reflect translation of the cranium to the axis, another factor influencing the oropharyngeal space in patients with atlantoaxial subluxation.
On the other hand, because of a wide individual variability in toxic anthracycline doses (von Hoff et al, 1979; Schwartz et al, 1987), cardiotoxicity may occur at unexpectedly low cumulative doses.
Delineation of pathophysiological mechanisms in human heart is difficult because of wide inter-individual variance, including age, medication, state of disease etc. Human tissue also offers a limited choice of truly independent variables, such as time, disease stage and treatment options.
This is in part because of wide variations between individuals, in part because the animal is related to its environment in a much more complex manner than is represented by this index, and in part because of the cooling measures applied, that help to relieve some of the heat stress.
Because of the wide inter-individual variation in E2 levels there was no clear relationship between E2 and LMP.
Warfarin therapy is complicated because of the wide inter-individual variation in response and dose requirements for adequate anticoagulation, narrow therapeutic range [international normalized ratio (INR), 2.0 3.0 for AF], need for chronic anticoagulation monitoring, potentially life-threatening interaction with numerous foods and drugs, and long onset and offset of action.
Because of the wide variability in individual vasopressor requirement, the absolute maximum dose of vasopressor is difficult to determine.
Because wide inter-individual variations in activity of many of the CYP enzymes have been related to the existence of genetic polymorphisms, there is an opportunity to look for inherited metabolic susceptibilities to CRC.
Because of the wide range of cognitive function, individual cognitive tests are subject to floor and ceiling artifacts [ 72].
