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This is in stark contrast with small-molecule nuclear import inhibitors directed at Impβ1 that prevent binding to RanGTP/cargo release [ 10, 14], which are mostly unsuitable for live-cell work because of uptake and precipitation issues and not highly efficient in inhibiting nuclear import in all cells.
Occasionally, false-positive readings may occur because of uptake in mature ganglioneuroma or other neuroendocrine tumours, or because of physiological uptake that may be mistaken for tumour in the adrenal gland, salivary gland, nasopharynx, brown fat or excretion through renal pelvis and bladder (Pfluger et al, 2003).
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When displacement is strong and sustained, plasma total [Trp] is usually decreased, because of enhanced uptake by tissues and the rapid equilibration between the free and albumin-bound fractions (Badawy, 2010).
Indeed, calcium, iron, and phosphate were shown to compete with Pb for absorption through the intestine because of similar uptake mechanisms, although Pb uptake was not evidenced to occur via active iron transporters or calcium channels [30, 34].
Oxygen isotopes are useful for geologic studies because the rate of uptake of the different isotopes by marine organisms is temperature-dependent.
Some commissioners had begun to withdraw services from pharmacies because low levels of uptake had made them non viable.
This observation could be predicted because the rate of uptake and tissue accumulation of Cd in women is higher than in men, as discussed above.
The fact that uptake did not increase further could be explained because the level of uptake was statistically indistinguishable from the level of viability (Student's t-test, p = 0.23), meaning that essentially all viable cells had uptake.
Although it is known that bone metastasis of prostate cancer primarily occurs in the pelvis and lumbar spine, the evaluation of quantitative uptake in these areas would be difficult because of bowel uptake on planar images.
Sports network ESPN is to close its 3D channel in the US because of a lack of uptake.
Moreover, chemicals such as cadmium (Cd) are known to affect food uptake, e.g. via feeding inhibition, hence energy budget results could be because of decreased uptake and not direct toxicity.
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