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Because of unacceptable side effects in subsequent examinations, further studies of ATP in humans were suspended.
The treatment was not completed in 8 cases: 6 in the QT group because of unacceptable side effects (UBT control was achieved in all), and 2 in the OAR group, because of loss of follow up.
Similar(56)
But the National Osteoporosis Society NOSsaidaboutbout a quarter of patients with the disease were unable to take alendronate because of unacceptable side-effects.
Patients were treated until progression or development of unacceptable side effects, and crossover to everolimus was allowed on progression.
Drug treatment can be either the facilitator which gives the opportunities, or the opposite, an intensifier of problems by occurrence of unacceptable side effects leading to decreased QoL.
In case of unacceptable side effects the dose was to be lowered by 25% to 38 µg/kg/day for the rest of the study.
Although patients may initially experience symptom relief with good tolerance, the majority will ultimately discontinue therapy because of inadequate response or unacceptable side effects [ 17, 21, 22].
Many multicenter clinical trials of potential neuroprotective agents showed either lack of efficacy or unacceptable side effects, but antioxidant therapy shows promise.
In the case of intolerability or unacceptable side effects, switching between the oral preparations or with one of the injectable preparations should be considered.
Treatment was discontinued in cases of disease progression, unacceptable side effects, or at a patient's request.
Despite the efforts, most of the new drug candidates failed because of their poor pharmacokinetic properties and/or unacceptable side effects.
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