Because of removal of two critical phosphorylation sites, our MAP tau is not subject to hyperphosphorylation. Beyond that, the targeted nature of MAP-based CFPs prevents them from accumulating in the extracellular space of the central and peripheral nervous system.
These antitumour effects of the combination therapy may be because of near-complete blockade of two critical signalling pathways downstream of ErbB-2: ERK1/2 and AKT1.
Because the two critical SNPs of rs4917 and rs4918 are present in the vicinities of exon-intron junctions, the linked substitutions potentially affect splicing of transcripts [ 31].
Because MAPK inhibitors did not reduce the DNA-binding activity of NF-κB, these two critical signaling pathways may be independently involved in S100A8/A9-mediated cytokine production.
This is critical because of two key factors: abstinence and tolerance.
We think our model might reflect the actual operation of the cerebellar learning system, because available knowledge supports the existence of the four critical features of the model.
Because the asj mice demonstrated residual enzyme activity, yet western analysis showed the presence of little, if any, ENPP1 protein, two critical experiments were performed.
It is particularly interesting because one critical aspect of alcohol dependence is the lasting alterations in gene expressions during withdrawal adaptations.
Proteinase K digestion has also been demonstrated by many laboratories to be critical in RNA extraction protocol [ 1, 3, 21, 22] possibly because of two functions.
He was critical chiefly because, of the three main candidates, Obama seemed to him the most conservative (his health plan, for instance, didn't mandate universal coverage), but it wasn't just his policies that Krugman objected to.
