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Almost 90percentt of drugs that get into Phase One [the earliest stage of clinical trials] don't make it to market because of toxicity or they actually don't work or they can't be manufactured on a scale that's needed to be safely produced and distributed in a global market.
No delays were noticed in the administration of treatment because of toxicity or other reasons.
A total of 22% chemotherapy cycles were delayed because of toxicity or upon patients' request.
Several chemical inhibitors of MMP-2 are in various stages of clinical testing but most have failed because of toxicity or lack of specificity.
Patients who stopped treatment because of toxicity or refusal or death before restaging were defined as nonresponders in the calculation of response rate.
Cetuximab may be continued if chemotherapy is stopped because of toxicity or patient choice, but should be discontinued on evidence of disease progression or unacceptable cetuximab toxicity.
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One hypothesis is that increased volatility in serum biomarkers when temporarily discontinuing therapy (because of toxicities or lack of compliance) may confound statistical analysis.
The secondary outcome of the study was assessment of safety and tolerability of ART, measured by the proportion of the subjects with toxicities and the proportion of subjects changed/discontinued ART because of toxicities or treatment failure.
There is a tendency to withhold therapy in some elderly patients because of fear of toxicity or concern about co-morbidity.
Acceptable uncertainty will be specific to particular evaluations and chemicals, perhaps because of their level of toxicity or exposure levels or because of the proximity to the regulatory decision point or simply the risk of being wrong; it will be specific to particular endpoints, given their different levels of impact.
Initially, it kills off some of the underlying and surrounding vegetation, possibly because of nitrogen toxicity or because of antibiotics found in the body, which are secreted by insect larvae as they feed on the flesh.
More suggestions(15)
because of sickness or
because of inertia or
because of racism or
because of injury or
because of famine or
because of cost or
because of shame or
because of lighting or
because of soot or
because of neglect or
because of race or
because of coyness or
because of expertise or
because of maintenance or
because of behavior or
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com