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It could be considered as a possible damage result because of toxicity of the high nanoparticle dose.
We have been unable to investigate the latter hypothesis in vivo because of toxicity of NMM-targeted compounds, such as blebbistatin, to X. tropicalis.
In the present study, no patient died or was excluded because of toxicity of the treatment; nor was there a significant delay in conducting the autologous transplantation.
Another possibility is that cell inactivation at the interface can occur because of toxicity of highly concentrated substrate rather than the IL itself.
The clinical use of these drugs to suppress nonsense mutations is precluded because of toxicity of these drugs at high dose, required for a low level of read through of premature nonsense codons.
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It has become clear that the quality of life of patients and the economic costs of supportive therapies needed because of toxicities of cancer therapies are significant concerns.
New drugs against these parasites are urgently required because of toxicities of existing therapies, the lack of pediatric formulations and the emergence of drug-resistant strains.
The remaining 204 (40.6%) subjects discontinued study participation before 18 months, principally because of toxicities of the AI to which they were assigned, as previously described (Henry et al, 2012).
Schultz appeared on the show on Tuesday and said that he, a lifelong Democrat, felt compelled to run as an independent "because of the toxicity and the lack of compromise of both parties".
An interim analysis performed in August 2003 revealed that 32% of patients required a dose reduction of oxaliplatin because of toxicity.
The carboplatin dose was changed to an AUC of 4.5 because of toxicity, with cycles repeated every 3 weeks.
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Justyna Jupowicz-Kozak
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