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Treatment was stopped because of toxicity in 4 patients.
9 The chemotherapy dose was modified because of toxicity in 12 patients.
The inhibition of AGE formation, amino-guanidine, was discontinued because of toxicity in humans.
Gemcitabine was not administered in 7 cycles because of toxicity, in 3 due to logistic problems, and in one because of treatment interruption following disease progression (Table 3).
The dose of irinotecan on day 15, however, was frequently omitted because of toxicity in both regimens (Noda et al, 2002; Sekine et al, 2003).
Importantly, fewer patients discontinued treatment because of toxicity in the abiraterone acetate group compared to the control group (13% vs. 18%, respectively) [ 5].
Similar(50)
Two patients who were withdrawn from the study because of the appearance of toxicity in cycle 1 were considered as not evaluable.
Early treatment interruption was required in five patients because of toxicity and in four patients due to disease progression.
Non-completion of treatment because of toxicity occurred in 23 patients, 39.1% (9/23) of whom had no greater than grade 2 toxicity.
Early treatment discontinuation because of toxicity occurred in 23 patients (21.3%), 39.1% (9/23) of whom had no greater than grade 2 toxicity.
There were two early deaths, three early withdrawals because of toxicity, and in two patients the data was insufficient to evaluate response.
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