Sentence examples for because of tolerability issues from inspiring English sources

The currently approved drugs have not fulfilled expectations, probably because of tolerability issues rather than lack of efficacy [ 3].

BAK-free travoprost 0.004 % is a viable alternative for patients who require switching their IOP-lowering medications because of tolerability issues.

2 In clinical practice, approximately one-third of patients with RA are being treated with biologic monotherapy, 3 5 often because of tolerability issues with methotrexate.

However, an open-label switching trial in patients who required alternative IOP-lowering therapy because of tolerability issues demonstrated a significant reduction in IOP after 3 months when patients were switched from latanoprost 0.005% to TRAV (n = 476) [ 25].

Subjects in the two double-blind studies were eligible for the open-label study if they had completed at least 24 days of previous double-blind treatment or discontinued because of tolerability issues, if they were expected to benefit from continuation of treatment, and if they had no other serious, unstable illnesses and were otherwise physically healthy.

Patients with open-angle glaucoma or ocular hypertension who, in the opinion of the investigator, would benefit from discontinuation of latanoprost 0.005 % ophthalmic solution because of tolerability issues were transitioned to receive BAK-free travoprost 0.004 % (Travatan® preserved with PQ Alcon Laboratoriess, Inc., Fort Worth, TX) once daily at approximately 8  pm for 12 weeks.

Promising results have been seen in several clinical trials of cholinesterase inhibitors and no safety of tolerability issues have been noted.

Because of unmet needs (improvements in quality of life, tolerability issues, and limited response rates) with existing treatments for metastatic breast cancer lapatinib is one of about 50 new agents currently being evaluated in clinical trials (Mincey & Perez 2004).

This titration schedule was modified in the event of any tolerability issues.

For example, public health settings frequently include large numbers of difficult-to-stabilize patients who had been in treatment for a long time on an older medication not included in the state-of-the-art TMAP algorithm because of poor efficacy or tolerability issues.

Moreover, even for individuals capable of interferon treatment there is a universal desire to avoid interferon because of its safety and tolerability issues.