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Dolphin and porpoise species that have adapted to rivers and deltas around the world have long been considered some of the most vulnerable of marine mammals because of their restricted habitats.
Children with autism often struggle in school because of their restricted interests (usually characterized by one very intense passion), but Martin has found a way to turn this characteristic into a vehicle for learning.
CTAs are attractive targets for tumor immunotherapy because of their restricted expression patterns in normal human tissue.
Because of their restricted expression pattern CT antigens are regarded as potential targets for vaccine immunotherapy.
Because of their restricted expression, CTAs are considered relevant to cancer biology and their prognostic relevance has been assessed in the recent years by several studies for various malignancies [ 5, 6].
Vesicle transport such as clathrin- or caveolin-mediated uptake is likely for the smaller PS particles because of their restricted size of 60 nm for clathrin-coated vesicles and 120 nm for caveolin-coated vesicles but rather questionable for bigger spheres of 240 nm (for comprehensive reviews, see Conner and Schmid 2003; Hillaireau and Couvreur 2009).
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Because of their more restricted spatial and temporal patterns of expression, these genes are not expected to be as highly expressed in whole-organism libraries as the essential 'housekeeping' genes.
The CTAs are attractive targets for developing cancer-specific immunotherapy because of their highly restricted expression in normal tissues and broad expression in a wide range of tumours (Chitale et al, 2005).
Because of their more restricted spatial and temporal expression profiles, transcription factor genes are not expected to be as highly expressed as essential house-keeping genes in whole-organism libraries.
Of these, APOBEC3G and APOBEC3F have been extensively studied because of their ability to restrict human immunodeficiency virus (HIV) [23] [25].
This is because of the restricted recombination between their respective markers and RM6770, which is the marker most strongly associated with RHBV resistance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com