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Such complexes usually exist only in solution; because of their low stability, they cannot, in general, be isolated.
The challenge in identifying regulators of mature miRNAs is a lack of information on the sequence of primary miRNAs, which are difficult to amplify because of their low stability and expression levels.
Protein protein interactions are often not accessible to experimental study because of their low stability and the difficulties involved in producing the proteins and to assemble them in their native conformations.
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Deposition of copper nitride films are of significant interest because of their low thermal stability and semiconducting characteristics resulting in emerging applications in optical memories and laser writing.
This limited the application of commonly used organic modifiers of long carbon-chain alkyl ammonium salts because of their low thermal stability.
Bismuth containing nanomaterials recently received increasing attention with respect to environmental applications because of their low cost, high stability and nontoxicity.
S. pneumoniae-specific antimicrobials would be promising therapeutic agents, as such agents would not disturb the normal flora; however, peptides are usually difficult to employ as therapeutic agents because of their potentially low stability and bioavailability.
Iron oxides (including Fe3O4, α-Fe2O3 and γ-Fe2O3) are promising materials for these electrochemical devices because of their low cost, nontoxicity, good chemical stability and high theoretical capacity.
They are very attractive for use in drug development because of their low toxicity and high enzymatic stability.
However, Ti-complexes are advantageous for the hydroamination of alkynes because of their low cost, very low toxicity, good stability and better functional group tolerance [106].
Si3N4 and SiO2 films have been widely used as substrates because of their low mechanical stress and high chemical stability [46].
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