Sentence examples for because of their dose from inspiring English sources

Early broad spectrum MMP inhibitors directed towards the zinc region of the catalytic domain (inhibitors exploiting the hydroxamate function as a zinc-binding group) have been ineffective because of their dose limiting toxicity in the form of musculoskeletal syndrome (MSS), characterised by joint stiffness and inflammation [9].

The use of purine analogs in combination with simvastatin allows a reduction of their dose because of the synergic effect of the combination of these drugs.

Although randomized trials are critical for establishing cause-and-effect relationships between vitamin D supplementation and health outcomes, they will not address all the potential questions because of their fixed dose (or at most, a few doses) of vitamin D and narrow range of 25(OH D levels achieved by supplementation.

This is because of their lower dose rates which are a consequence of the longer half-life of Lu and the fractionation of the dose of In.

However, given the high rate of microscopically incomplete resections in pancreatic cancer (up to 75%) [ 4, 22- 24], external beam radiation therapy approaches alone seem to be insufficient regardless of their fractionation schedule because of their general dose limitations caused by the low tolerance of the surrounding organs at risk like small bowel and kidneys [ 25].

Because of their nonlinearity of dose [ 77], omeprazole and lansoprazole do not afford this same independence of dose.

Last year's cycle trial event showed how road closures can effectively reduce local traffic pollution but endurance athletes are especially vulnerable to ground-level ozone because of their accumulated pollution dose during long events.

A leak test can help assure that form-fill-seal patches are manufactured with zero tolerance for leaks because of their potential for dose dumping if leaking occurs.

In this clinical trial, the delivery of nitric oxide (NO) via transdermal GTN patches was chosen because of their ease of dosing and application.

Because of their non-classical dose-responses, they must be studied in detail to pinpoint effective concentrations and the directions of response changes.

Shigella spp. are etiologic agents of gastrointestinal disease worldwide and are frequently associated with outbreaks because of their low infectious doses and person-to-person transmission (1, 2 ).