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Also termed seven transmembrane (7TM) receptors because of their conserved core architecture of seven transmembrane alpha-helices, GPCRs can recognize and bind many diverse signaling molecules including odorants, neurotransmitters and hormones (Stevens et al., 2013).
Galectins are defined by their ability to recognize β-galactose because of their conserved carbohydrate-recognition domains (CRDs) of about 130 amino acids.
The CPC components are so-called because of their conserved relocalization from kinetochores to the spindle midzone during anaphase (Carmena et al. 2012).
From the discussions above, it is clear that the insulin/IGF system are prime suspects because of their conserved function in integrating tissue metabolism and growth.
Because of their conserved synteny and highly related sequences, we also applied the pan-genome analysis to the B. burgdorferi s.l. group of species, including B. valaisiana, B. afzelii, B. garinii, B. bissettii and B. spielmanii.
Proteins which contain highly conserved cores interspersed with or flanked by highly variable sequences might show lower average conservation than proteins accepting substitutions evenly throughout their length but remain detectable by BLAST because of their conserved core.
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Massive information for genetics, taxonomy, and phylogeny could be mined from cp genomes, because of their relatively conserved gene structure and sequence divergence between species and individuals (Parks et al. 2009; Huang et al. 2014).
Plastome sequences are often used for deep phylogenetics in plants because of their highly conserved gene order and low mutation rate.
In recent years, the Chlamydomonas reinhardtii Copper response regulator Crr1 and its closest Arabidopsis homolog SPL7 attracted attention because of their deeply conserved function as central orchestrators of Cu homeostasis [ 9, 10, 17].
Mitochondrial genomes of plants are evolutionarily intriguing because of their highly conserved genic content and slow rates of genic evolution [ 11– 13], features which contrast sharply with their highly labile genomic structure, genome size, DNA repair mechanisms and recombination induced by different types and origins of repeated sequences.
The genes encoding the HAO/HZO proteins appear to be suitable as functional and phylogenetic biomarkers because of their highly conserved sequence across different species (Klotz et al. 2008), and recently, several sets of degenerate primers were designed based on the available hao/ hzo sequences (Schmid et al. 2008).
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