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Author's response: The aminoacyl-tRNA synthetases are a special case because the combination of their trees and knowledge of the essentiality of their function implies these are displacements.
His notion of the essentiality of religion is remarkably individualistic, removed from all social contingencies.
These effects contradict the original goal of the essentiality analysis.
Comparison of the essentiality predictions made by the aforementioned models is not a trivial task.
Because the essentiality of a reaction depends on the availability of external substrates and thus on the composition of the external medium, it is an interesting problem of topological network analysis to predict minimal sets of external substrates allowing the network to produce a prescribed output and to check such predictions experimentally (Klamt 2006).
This example is of course related to the essentiality of origin (as discussed in Kripke 1980).
There are various types of features related to the essentiality of proteins.
We discovered interesting correlations of our features to the essentiality of a gene.
Because there are different types of features that relates to protein essentiality, which suggests that multiple aspects of organisms contribute to determining the essentiality of proteins [ 18].
We used FBA of the metabolic networks to predict the essentiality of single genes.
First, because the study by Plata et al. aimed at predicting the essentiality of genes, whereas the other studies assessed the essentiality of enzymes, the predictions made do not overlap when gene-to-enzyme relations are not one-to-one.
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