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The evaluation of complex interventions requires a phased approach, because of specific difficulties in developing, identifying, documenting, and reproducing the intervention.
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Since the diagnosis of AS poses some specific difficulties because of proteinase K susceptibility and variable distribution of PrPRes [ 4], EFSA also evaluated the sensitivity of the different TSE rapid tests to detect AS on different biological material (table 1) [ 5, 6].
Furthermore, research on Mirena presents some specific difficulties in interpretation because of the high proportion of women discontinuing treatment.
Because working memory difficulties are increasingly recognised as a hallmark feature of specific learning difficulties (e.g. Rose, 2009), as well as slow rates of learning more generally (e.g. Gathercole & Alloway, 2008), these findings have practical implications.
"There are specific difficulties for the first years of free schools.
However, all these studies excluded patients with transverse colon and splenic flexure lesions, probably because of technical difficulties specific to this location, as identification of middle and left colic vessels and anastomosis construction.
Nevertheless, it is still challenging to study the geometry (such as shape) of the white matter tracts revealed by DTI and its relationship with AD because of difficulties in quantifying specific white matter structures visualized by the DTI acquisition.
Third, because of obvious difficulties in obtaining the specific tissue derived from trigeminovascular or cerebral biopsies, we cannot provide direct evidence that epigenetic modulation is involved in migraine.
In the previous issue of Critical Care, Ware and colleagues describe a clinical study using multiple host biomarkers to aid diagnosis of acute respiratory distress syndrome (ARDS), a particular complication of sepsis which is often under-diagnosed because of the difficulties in applying a non-specific definition of disease [ 1].
Dr. de Heer had been working with nanotubes, but said they looked like a dead end, because of the difficulties in producing nanotubes of a specific type and length, placing them precisely and attaching wires.
Restricting the use of single distribution resampling in case of the memory of specific computing devices causes difficulties for the developer, because of the additional time and effort needed to develop a particle filter.
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