The validity of existing studies from outside Germany was questioned by fire departments because of presumed specific differences in the professional career in Germany like frequent life long employment, work till later age, remaining a fire fighters longer because of specific German pension benefits.
Because of species specific differences in the interaction between human rFVIIa and animal tissue factor, comments regarding dosing remain guarded.
This could be because of species specific differences in cell-cycle control mechanisms, which in Oikopleura involves endocycling, and not necessarily mitosis [ 38].
However, the appropriateness of the animal models used in these studies has been called into question because of the wide range of clearance rates observed between and within species and because of species-specific differences in the role of the peroxisome proliferator-activated receptor alpha mediated effects of PFOA (DeWitt et al. 2009; Lau et al. 2007; Rosen et al. 2009).
Thus, APOE seems to regulate Aβ levels in an APOE-isoform-dependent manner, probably because of isoform-specific differences in the capacity of APOE to modulate Aβ degradation.
However, those approaches might be inadequate because of distinct gender specific differences in tumor biology of breast cancer.
However, these responses will not be uniform in terms of timing and magnitude across the landscape because of site-specific differences in ecosystem susceptibility to climate forcing.
It is, however, important to note that extrapolation of gene expression from blood to liver is difficult because of tissue-specific differences in transcription factors and other regulating elements, as well as differences in metabolite distributions between blood and liver, that may affect the result.
The molecular mechanisms that regulate ovarian follicular development in mammals are poorly understood, mainly because of species-specific differences between mono-ovulatory and polyovulatory animals.
The low-P-medium was 1 µM P for Scenedesmus, 5 µM P for Cryptomonas and Chlamydomonas and 10 µM P for Cyclotella because of species-specific differences in their optimum phosphate requirements.
