Sentence examples for because of significant toxicity from inspiring English sources

Because of significant toxicity and limited activity, further investigation of irinotecan plus docetaxel in second line NSCLC is not recommended.

The protocol was subsequently amended to include a lower starting dose of MK-0457 322 mg/m/h) because of significant toxicity at 40 mg/m/h.

7– 10 Although the development of the former was discontinued because of significant toxicity, 3 HAP exhibited anti-HBV efficacy in the absence of robust toxicity.

However, 'pure' PDGFR inhibition needs to be approached with caution as a phase II study of CDP860, a pegylated di-Fab' molecule that binds to and blocks the activity of the β-subunit of PDGFR, was stopped early because of significant toxicity due to fluid accumulation (Jayson et al, 2005).

There have been no human trials of Fas/FasL agonists or antagonists in the treatment of HIV infection to date because of significant toxicities in pre-clinical studies.

Other systemic treatment options such as pentavalent antimony, pentamidine, amphotericin B or miltefosine should be reserved for complex or complicated disease because of the risk of significant toxicity.

We confirm the lack of significant toxicity of this drug.

In the event of significant toxicity, dose reductions were implemented.

Doxorubicin had been accepted by most countries as the only systemic treatment, which has traditionally been a limited option due to the rarity of complete and partial responses and because of its significant toxicity [ 5].

The sirolimus dose was also reduced because of any significant toxicity attributed to sirolimus.

But because of its significant toxicity, trials with this drug were discontinued (Newlands et al, 1996).