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Of the remaining 93 HBsAg-positive volunteers, 18 volunteers declined to participate for personal reasons, probably related to the amount of visits and phlebotomy, and 3 were excluded: 2 because of sickle cell disease, and 1 lost HBsAg before the start of the study.
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The second patient was a 14-year-old boy in whom meningitis developed and who died 6 days later because of complications of sickle cell disease (9 ).
One subject was excluded from analysis after screening because of a diagnosis of sickle cell trait.
He had no evidence of sickle cell disease or any other congenital blood disorders.
The medical examiner for Bay County, Dr. Charles Siebert, ruled after an autopsy that the boy had died of sickle cell trait.
For example, although many different populations in Africa suffer from a high prevalence of sickle cell anemia, some tend to be more mildly affected than others because they continue to produce fetal hemoglobin, which blocks or limits aggregation of the mutant "sickle cell" hemoglobin protein.
Renal medullary carcinoma (RMC) is a rare and highly aggressive neoplasm that most often occurs in the setting of sickle cell trait or sickle cell disease (SCD).
The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria.
Her mom died from complications of sickle cell disease when she and her twin sister were ten years old.
In the case of sickle cell, the gene has a beneficial aspect: it provides protection against malaria.
Not so in Angola, where the burden of sickle cell disease is immense and accurate statistics are not even available.
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CEO of Professional Science Editing for Scientists @ prosciediting.com