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Moreover, prophylaxis is often not satisfactory because of secondary effects.
The high dose of OP3-4 may seem to reduce the clinical score because of secondary effects resulting from the prevention of CIA-induced bone loss.
In summary, we show that combining microarray data with motif analysis, lets us distinguish between the genes that are direct targets of a transcription factor and those that are modulated because of secondary effects.
Regarding 55 eyes for which treatment was discontinued, 12 patients stopped treatment and 12 died, physicians stopped treatment because of secondary effects (2 eyes) or lack of efficacy (25 eyes), and 4 eyes stopped for other reasons.
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They said, in a concurring opinion by Justice Scalia, that there was no need to consider the presence or absence of "secondary effects" because "the traditional power of government to foster good morals (bonos mores) and the acceptability of the traditional judgment (if Erie wishes to endorse it) that nude public dancing itself is immoral have not been repealed by the First Amendment".
Top predators are of particular interest in this context, because their removal can generate substantial cascades of secondary effects on community composition.
The argument for the free market is a complicated and sophisticated one and depends on demonstration of secondary effects.
These studies have shown that if additional therapy is directed to the CNS early, it is possible to replace radiotherapy, which may be reserved only for those patients with a higher risk of relapse or with CNS3 status, because of its secondary effects, which have been observed in long-term survivors of ALL after either chemotherapy or radiotherapy [ 36– 36].
Inflammations of the uveal tract are always potentially serious because of the secondary effects they may have on other intraocular structures.
This process could be even more challenging for patients who have already started chemotherapy (as was the case of most of our retest participants) because common secondary effects of chemotherapy include memory loss and difficulty concentrating [ 42].
It is worthwhile to note that recording of PERG and PVEP tests in patients with AD is not easy because of the possible secondary effects of defocus or other behavioral problems.
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