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In our hands, methods using cell permeabilization failed to label the condensed central HC probably because of reduced accessibility (data not shown).
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As reduced accessibility of pericentromeric heterochromatin and long inaccessible genes required DNA methylation, it appears that PcG proteins and DNA methylation establish inaccessible chromatin in plants.
Similar to repression of sequences in constitutive heterochromatin, silencing of genes targeted by PcG proteins was proposed to result in reduced accessibility.
Others are designed for use by a specific group, like Indian Heath Service hospital EDs, or may have reduced accessibility because of their secure location, like military hospital EDs.
Regrowth of paths due to abandonment of seasonal farming has reduced accessibility.
While the current attack on libraries is not so drastic, we already have much reduced accessibility to variety of view and expertise.
Could it reflect reduced accessibility to dental care associated with place of residence?
Therefore, the reduced accessibility seems to be preferentially associated with repression of transcription from alternative promoters.
For instance, one could expect higher quality to reduce accessibility, because it makes ECEC more expensive.
Reducing cohort size is tantamount to reducing accessibility.
Binding of heparin did not detectably affect catalysis of peptide substrates, but may reduce accessibility of proteinase to protein substrates.
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CEO of Professional Science Editing for Scientists @ prosciediting.com