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That implies that this must have happened because of positive selection," Lahn said, pointing out that it is statistically unlikely for a haplogroup this young to have such high frequency as a result of mere random genetic drift.
Many Drosophila Acps evolve rapidly because of positive selection due to sexual conflict [ 4- 12].
This finding is expected because of positive selection bias of the patients who tolerate the drug and less frequent visits in ReAlise, and generally aligns with data from ADA clinical trials and registries [ 4, 7, 18, 23- 25].
If this haplotype undergoes a rapid increase in frequency because of positive selection, there is little time for recombination events to break the ancestral links with nearby genetic markers [ 24].
The proteins that bind to animal and plant centromeres also contain rapidly evolving regions, and this could be because of positive selection for mutations that suppress meiotic drive of centromeres during female meiosis [ 1, 27].
On the other hand, egg coat ZP proteins rapidly evolve because of positive selection [ 19]; therefore, it is difficult to infer correct phylogenetic relationships of the invertebrate and vertebrate egg coat ZPs even they had possessed a common ancestor.
Similar(53)
Because signatures of positive selection may be retained for very long periods of evolutionary time [ 53], these inconsistent results of selection tests probably reflect ancient pseudogenization of once functional MHC sequences.
Because detection of positive selection is sensitive to the number of sequences used [ 46], analyses were repeated using a total of 8 mammalian genomes (human, chimpanzee, gorilla, orangutan, macaque, marmoset, mouse and rat).
Because tests of positive selection are sensitive to sequencing, annotation and alignment errors (Talavera and Castresana 2007; Scheinfeldt et al. 2009), we used highly stringent criteria to filter our alignments.
One has to keep in mind that the results of the positive selection test should be treated with caution because estimates of positive selection among members of multi-gene families may be flawed if there are homogenizing effects caused by gene conversion within the family [ 60].
Because the mechanism of positive selection occurs at the double positive stage (35), we favor the possibility that all T cells are selected on the VP2 antigen and are deleted from the active repertoire independent of CD4 or CD8 expression.
More suggestions(15)
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because of potential selection
because of natural selection
because of positive peritoneal
because of positive Tg
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because of positive tuberculin
because of positive syphilitic
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