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None of the methods appeared to produce spurious peaks because of population stratification.
Alternatively, a false-positive association may have occurred in the Toronto PsA cohort because of population stratification.
Conventional case control gene association studies have been known to produce false-positive results partly because of population stratification as well as poor study design [ 26].
The value of genomic control inflation factor (λGC) was 1.008, which indicated that inflation of association test statistics because of population stratification was negligible.
Visual inspection showed very little individual admixture within each self-identified ethnic group, indicating a small potential for confounding because of population stratification.
Although case control association studies are the most common, they have high type I errors because of population stratification (Spielman et al. 1993; Zhang et al. 2003).
Similar(52)
The within-family effect is free of the potential effects of population stratification, because sibling pairs are drawn from the same family, and thus from the same genetic stratum.
Because of potential issues of population stratification when including non-white subjects in each study, we restricted our primary analyses to subjects who self-reported as white.
Family-based association designs are popular, because they offer inherent control of population stratification based on age, sex, ethnicity, and environmental exposure.
The likelihood of population stratification was considered low because there is no evidence to date of population stratification for the phenotypes under consideration (i.e., craving, relative value of alcohol, affect).
The possibility of population stratification was not examined because genome-wide data was only available for the WTCCC data set.
More suggestions(12)
because of age stratification
because of population demand
because of population admixture
because of population growth
because of population movement
because of population pressure
because of population mobility
because of population expansion
because of population increase
because of population implosion
because of population homogeneity
because of population distribution
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