The major challenges are: reproducible manufacturing and scale-up, availability of appropriate characterization methods, instability under in vivo environments, safety issues, poor understanding of the disease heterogeneity and patient preselection strategies, regulatory barriers and inadequate understanding of the biophysical and chemical interactions of nanoformulations.
The relatively low percentage (21%%) of pathological exams in our population underlines the need for good patient preselection.
Another advantage is the conduct of the study in a standard supply hospital with a large catchment area to get a cross-section of patients and avoid preselection concerning, e.g., comorbidity [ 37].
If confirmed in a larger patient population, a diagnostic test based on this panel could improve early detection of cancerous lesions by allowing preselection of patients with precancerous colorectal lesions that could be subsequently be removed by colonoscopy, thereby offering the potential to prevent colorectal cancer.
This could lead to an easy tool for prediction of a patient's tolerance of planned chemotherapy with TMZ and lead to preselection of patients to be treated.
This fact may be due to preselection of patients in clinical trials; therefore, the incidence of cardiotoxic effects in unselected patient populations needs to be critically monitored.
The preselection of patients on the basis of genetic factors that predict treatment sensitivity or resistance may thus be required for the combination therapy with nimotuzumab and radiation.
To avoid bias from the preselection of patients, one should seek studies where all consecutive ICU admissions, independent of diagnosis, length of stay, mode of ventilation, etc. were included and the epidemiology of IAH addressed.
Preselection of patients for HDAC6 therapy using the HDAC6 score as a predictive biomarker may be applicable not only to IBCs but also to non-IBCs and other tumors.
Although the overall prediction does not appear to be that strong, further optimization and preselection of patients on the basis of uniform disease-modifying anti-rheumatic drug (DMARD) treatment regimens are likely to yield stronger predictive values.
